Modulating Phagocyte Activation
نویسندگان
چکیده
منابع مشابه
Modulating Phagocyte Activation
Helicobacter pylori (Hp) is a highly successful human pathogen that has colonized the gastric mucosa of approximately half of the world’s population. Infection with this gram-negative bacterium induces a state of chronic inflammation that does not resolve the underlying infection and often leads to gastric or duodenal ulcers or more rarely to gastric adenocarcinoma or mucosa-associated lymphoid...
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Helicobacter pylori (Hp) is a highly successful human pathogen that has colonized the gastric mucosa of approximately half of the world’s population. Infection with this gram-negative bacterium induces a state of chronic inflammation that does not resolve the underlying infection and often leads to gastric or duodenal ulcers or more rarely to gastric adenocarcinoma or mucosa-associated lymphoid...
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Activation of phagocyte NADPH oxidase requires interaction between p47 and p22. p47 in resting phagocytes does not bind p22. Phosphorylation of serines in the p47 C terminus enables binding to the p22 C terminus by inducing a conformational change in p47 that unmasks the SH3A domain. We report that an arginine/lysine-rich region in the p47 C terminus binds the p47 SH3 domains expressed in tande...
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We investigated the effect of both immune and normal sera on the binding of free Plasmodium berghei by resident and activated macrophages. Resident macrophages bound plasmodia to a greater extent than did activated macrophages, regardless of treatment. Resident macrophages bound free plasmodia, predominantly trophozoites, in the presence of normal serum by a mechanism inhibited by N-acetylgluco...
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Nef, a multifunctional HIV protein, activates the Vav/Rac/p21-activated kinase (PAK) signaling pathway. Given the potential role of this pathway in the activation of the phagocyte NADPH oxidase, we have investigated the effect of the HIV-1 Nef protein on the phagocyte respiratory burst. Microglia (cell line and primary culture) were transduced with lentiviral expression vectors. Expression of N...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 2000
ISSN: 0022-1007,1540-9538
DOI: 10.1084/jem.191.9.1451